Cellulite on Legs — Bellezza Clinic London

The Science Behind

The arrangement of the superficial adipose tissue is different in men and women. In men, fat is deposited mainly at the level of the upper portion of the body, while in women it is deposited mainly in the lower part. In addition to the different arrangement, body fat also presents a different ease of metabolization. The fat of the upper body is metabolized more easily than that of the lower body in women.

This phenomenon reveals an evolutionary function. The woman has the task of procreating and providing food support to the new-born, regardless of her feeding situation. For this reason, the fat of the lower part of the body is resistant to any energy request until the moment of delivery in which it becomes sensitive to lipolysis, freeing the fatty acids necessary for the energy needs of the infant.

Estrogens, as well as insulin, act at the level of adipocyte DNA by stimulating an operon, PPAR (perissosome activation receptor), which induces the synthesis of liposynthetic enzymes and shifts the construction / destruction balance towards construction

Another peculiarity of the adipose tissue is that of having a low amount of water (18%) compared to other tissues (60%).

Let us now examine some available treatments considering that aesthetic problems (habitus and muscles) must mainly be solved by the patient (physical activity).

So let’s analyse PEFS as a pathology.

The term edemato-fibro-sclerotic panniculopathy refers to an alteration of the microcirculation of the adipose tissue with a tendency to evolution and chronicization, which induces an increase in volume at the trochanteric level.

Let’s analyse the etiopathogenesis of PEFS. This arises from an alteration of Sterling’s equilibrium which follows a venolymphatic stasis and consequent slowdown in the outflow of tissue fluids and tissue hypoxia.

The modification of the microcirculation of the adipose tissue leads to its chronic alteration (panniculopathy) which evolves over time first into an oedema, then into a fibrosis and, finally, into a sclerosis.

What contributes to causing Cellulite

As in all “pathologies”, treatment must begin with the elimination of the triggering causes.

An increase in weight on the lower limbs slows down the return circulation.

A diet rich in simple carbohydrates and salts, substances with a high hygroscopic action, increases tissue water retention.

Constipation causes stagnation of the faecal mass in the intestine, which compressing the iliac veins leads to circulatory stasis in the lower limbs.

The absolute, relative or iatrogenic increase of estrogen determines the activation of vasoactive quinines which, by increasing the vessel permeability, induce edema. Hyperestrenism (excess estrogen) can be assessed with the dilution test. One liter of water is drunk with an empty bladder and the quantity of urine emitted in the following four hours is measured (without eating or drinking). A normal value must be greater than 900 cc. The test is performed on the 7th and 21st day from the beginning of the menstrual cycle.

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