Cosmetic

Gencor study shows Ageratum conyzoides may be effective against hair loss

Ageratum Conyzoides L. ​has traditionally been used in the Caribbean for prostate and urinary health. However, the pilot, open-label, randomized, parallel and in vitro​ study published in the Journal of Cosmetology and Trichology​​ assessed the efficacy and safety of the hair loss formulation with results showing it as an effective treatment option.

“Hair loss is a billion-dollar industry with projections showing continued growth,”​ said Chase Shryoc, Vice President of Sales & Business Development for Gencor. “This is an exciting next step for Gencor as we launch our first innovation in the cosmetology market.”

Study

The study was aimed to determine the effect of an Ageratum conyzoides​ extract on the gene expression of 5α-reductase, the enzyme that converts testosterone to Dihydrotestosterone (DHT), a major driver of AGA, or androgenetic alopecia (pattern hair loss) along with another likely cause, the release of Prostaglandin D2 (PGD2) in Human Hair Dermal Papilla Cells (HHDPC).

28 healthy male and females over 18 years of age that were exhibiting pattern baldness received either a 0.5% or 1% strength A. conyzoides​ gel formulation to be applied topically twice per day for 8 weeks.

Hair growth was measured by temporal recession distance and the participants’ quality of life was assessed by the Hair Distress Questionnaire.

Results

Temporal recession in men reduced from 9.1 to 8.6 cm in the 1% group and from 8.6 to 7.5 cm in the 0.5% group, where normal distance in men without recession is 6-6.5 cm. Although this was not a significantly different result from baseline (p=0.084), it did indicate a trend towards significance. Due to a small sample size, the scores of female participants were not included.


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